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    • 5. 发明授权
    • Film-forming teat sealer for prevention of mastitis and use thereof
    • 用于预防乳腺炎的成膜乳头密封剂及其用途
    • US5017369A
    • 1991-05-21
    • US372283
    • 1989-06-27
    • Virginia C. Marhevka
    • Virginia C. Marhevka
    • A61K9/00
    • A61K9/0041
    • The disclosed teat sealer comprises:a major amount (e.g.>65 wt.-%) aqueous solvent medium, and more than 1 wt.-% but less than about 16 wt.-% (preferably 2-12 wt.-%) partially hydrolyzed grade polyvinyl alcohol containing at least about 2 mole-% (e.g. 4-30 mole-%) residual vinyl acetate units dissolved in the aqueous medium.an antimicrobially effective amount (e.g. 0.1-10%) of antimicrobial agent, such as a biguanidine salt which is compatible with aqueous polyvinyl alcohol;from 0 to about 10% by weight of an opacifying agent such as a polymeric latex containing 15-70% by weight polymer solids, the latax being uniformly distributed through the aqueous medium in a stable manner, andoptionally (but preferably) a water-soluble dye dissolved in the aqueous medium to impart to the composition a color such as blue.This teat sealing composition is effective against a variety of mastitis organisms and is strongly adherent to bovine teat skin under field conditions but is also easily removed with a simple water-washing technique. In using the composition, the teats of the animal are coated in a conventional manner, and the resulting coating is permitted to dry to an adherent film. A plug-like deposit forms at the teat end. This deposit adheres even more strongly to the animal's teats than the rest of the coating.
    • 所公开的奶头封口机包括:主要量(例如> 65重量%)的含水溶剂介质和大于1重量%但小于约16重量%(优选2-12重量%)的部分 含有溶解在水介质中的至少约2摩尔%(例如4-30摩尔%)残余乙酸乙烯酯单元的水解级聚乙烯醇。 抗微生物剂(例如0.1-10%)的抗微生物剂如与聚乙烯醇水溶液相容的双胍胺盐; 0至约10重量%的不透明剂,例如含有15-70重量%聚合物固体的聚合物胶乳,所述数均分子通过水性介质以稳定的方式均匀分布,以及任选(但优选) 可溶性染料溶解在水性介质中以赋予组合物诸如蓝色的颜色。 这种乳头密封组合物对各种乳腺炎生物有效,并且在现场条件下对牛奶皮肤有很强的附着力,但是也可以用简单的水洗技术容易地去除。 在使用组合物时,以常规方式涂覆动物的乳头,并将所得到的涂层干燥成粘附膜。 在奶头端形成一个塞子形式的存款。 与其他涂层相比,这种沉积物比动物的乳头更加牢固。